Tradjenta side effects: What you should know

Tradjenta (linagliptin) is a brand-name prescription medication. It’s approved by the Food and Drug Administration (FDA) to improve Blood sugar levels in adults with Type 2 diabetes.

Tradjenta is typically used as a long-term treatment.

Here are some fast facts about Tradjenta:

  • Active ingredient: linagliptin
  • Drug class: dipeptidyl peptidase-4 (DPP-4) inhibitor
  • Drug strength: 5 milligrams (mg)
  • Drug form: oral tablets

Like other drugs, Tradjenta can cause side effects. Read on to learn about potential common, mild, and serious side effects. 

Tradjenta can cause certain adverse effects (side effects), some of which are more common than others. 

These side effects may be temporary, lasting a few days to weeks. 

But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

These are just a few of the more common side effects reported by people who took Tradjenta in clinical trials:

  • stuffy or runny nose
  • sore throat
  • cough
  • Diarrhea

Mild side effects can occur with Tradjenta. This list doesn’t include all possible mild side effects of the drug. 

For more information, you can refer to Tradjenta’s prescribing information.

Mild side effects that have been reported with Tradjenta include:

These side effects may be temporary, lasting a few days to weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Tradjenta may cause serious side effects, but these aren’t common. The list below may not include all possible serious side effects of the drug. For more information, you can refer to Tradjenta’s prescribing information.

If you develop serious side effects while taking Tradjenta, call your doctor right away. 

If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Serious side effects that have been reported and their symptoms include:

  • Heart failure. Symptoms can include:
    • fluid retention causing swelling in your lower legs, ankles, or feet
    • shortness of breath
    • trouble breathing, especially while lying down
    • unusual, quick weight gain (such as gaining five pounds over a few days)
  • Pancreatitis. Symptoms can include:
    • severe abdominal pain, which may radiate to your back
    • nausea
    • vomiting
  • Severe joint pain.
  • Bullous pemphigoid.
  • Hypoglycemia (low blood sugar).
  • Allergic reaction.

Does Tradjenta cause weight gain?

It’s possible that Tradjenta can cause weight gain. This depends on whether Tradjenta is used in combination with other medications. But Tradjenta isn’t known to cause weight gain when taken on its own.

Other medications used to treat Diabetes can affect weight. It’s important to note that it’s not unusual for people with type 2 diabetes and high blood sugar levels to have weight gain.

Weight gain can also be a symptom of heart failure, a rare but serious side effect reported with Tradjenta.

Talk with your doctor or pharmacist if you’re concerned about your weight while taking Tradjenta. They can review your medications and identify which may be causing this side effect. They can also recommend ways for you to manage your weight.



Can Tradjenta cause side effects related to the kidneys?

No, Tradjenta isn’t known to cause side effects related to the kidneys.

It’s important to note that people with diabetes have an increased risk of kidney problems. This is because, over time, high blood sugar levels can damage the kidneys.

And certain other medications used to treat diabetes can cause kidney-related side effects. These include Invokana (canagliflozin) and Jardiance (empagliflozin).

If you have questions about your kidney health or function, talk with your doctor.

I’m taking Tradjenta with metformin. What side effects can I expect?

In clinical trials, the following side effects were common in people who took Tradjenta in combination with metformin:

  • cough
  • sore throat
  • stuffy or runny nose
  • diarrhea

Hypoglycemia (low blood sugar) and mild weight loss were also reported.

Keep in mind that, although rare, Tradjenta can also cause serious side effects. Your risk for serious side effects is the same whether you take Tradjenta with metformin or not.

If you have additional questions about taking Tradjenta and metformin together, talk with your doctor or pharmacist.

Does Tradjenta cause long-term side effects?

It’s possible. Long-term side effects that Tradjenta may cause include:

  • pancreatitis, which may happen at any time while taking Tradjenta
  • heart failure, which may require long-term treatment

However, keep in mind that pancreatitis and heart failure are very rare side effects of treatment with Tradjenta.

If you have additional questions about Tradjenta and long-term side effects, talk with your doctor.

Could a rash be a side effect of Tradjenta?

Possibly. A rash could also be a sign of an allergic reaction, a rare but possibly serious side effect of Tradjenta.

There were a few rare reports of a side effect called bullous pemphigoid by people taking Tradjenta in clinical trials. This is a rare but possibly serious condition that causes large, fluid-filled blisters on your skin.

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